ESCRIPTION GHK-Cu (Copper) Peptide — Research Grade GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) that has been studied for its roles in matrix signaling, metal chelation, and gene-expression programs in vitro and in animal models.(1,4–7) Plasma levels of native GHK have been reported to decline with age.(1) Key Facts Tripeptide that complexes with Cu(II) ions (GHK-Cu) Explored in models of tissue remodeling, antioxidant/anti-inflammatory pathways, and cell signaling(6–14) Studied for effects on collagen-associated proteins (e.g., decorin) and MMP/TIMP balance(6,7) Age-linked decline of circulating GHK noted in literature(1) Research Highlights (preclinical & in vitro) Matrix & Wound Models: GHK-Cu exposure has been associated with increased collagen-related outputs and wound-area improvements in animal and cell models; decorin and TIMP-1/-2 have been reported as downstream readouts.(6–8) Cell Signaling & Gene Programs: Studies describe broad transcriptional responses, including programs tied to stress responses and genome maintenance in select systems.(5) Oxidative/Inflammatory Pathways: Work in cell and animal models reports modulation of ROS, NF-κB/Nrf2-related readouts, and inflammatory cytokines under defined conditions.(13,14) Metal Handling: GHK shows selective chelation behavior; theoretical and experimental work explores interactions with iron handling and lipid peroxidation chemistry.(4,15) Behavioral/Exploratory Models: Rodent paradigms (thermal plate, anxiety maze, shock-induced aggression) have reported changes following GHK-Cu exposure under study conditions.(1,11,12) Specifications Peptide GHK-Cu (glycyl-L-histidyl-L-lysine • Cu2+) Molecular Formula C14H23CuN6O4 Molecular Weight 340.38 g/mol Form Lyophilized powder Purity ≥99% (HPLC; Certificate of Analysis available) Synonyms Gly-His-Lys-Cu; Glycyl-L-histidyl-L-lysine-copper (II) Storage & Handling Before reconstitution: Store in a cool, dry place, protected from light. After reconstitution: 2–8 °C for short-term; −20 °C for long-term stability. Avoid repeated freeze–thaw cycles. Notes This material is supplied for laboratory research only. Not for human use, clinical use, veterinary use, or household use. All literature references listed (e.g., (1,4–15)) correspond to publicly available studies on GHK/ GHk-Cu in cell/animal models and theoretical analyses.